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Unlike cisplatin and similarly to other antiarthritic gold drugs, auranofin appears to exert its activity through inhibition of enzyme activities rather than DNA damage
Lastly, significant downregulation of metabolic pathways such as bile acid metabolism, glycolysis, fatty acid metabolism, and oxidative phosphorylation could contribute to tumor suppression by regulating anti-tumor immunity and tumor growth (Fig
2.3 Temporary Interruption for Surgery Withhold JARDIANCE for at least 3 days, if possible, prior to surgery or procedures associated with prolonged fasting
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However, changes in hormones, energy levels, and side effects from the drug may also play a role